Vaterite coatings on electrospun polymeric fibers for biomedical applications

Maria S. Savelyeva, Anatoly A. Abalymov, German P. Lyubun, Irina V. Vidyasheva, Alexey M. Yashchenok, Timothy E.L. Douglas, Dmitry A. Gorin, Bogdan V. Parakhonskiy

Результат исследований: Вклад в журналСтатьярецензирование

40 Цитирования (Scopus)

Аннотация

The process of porous calcium carbonate (CaCO3) covering on electrospun poly(ε-caprolactone) (PCL) fibers is described in this study. Uniform CaCO3 coatings, composed of vaterite microparticles and its aggregates, were formed on PCL fibers by mineral precipitation from solution under ultrasonic treatment. The porous structure of CaCO3 in vaterite polymorphic form is useful for loading of various substances (drugs and nanoparticles), and this property makes vaterite an appropriate material for design of drug delivery systems. Such mineralization was implemented to attain therapeutic and/or biological activity of tissue engineering scaffolds based on electrospun PCL, by means of CaCO3 coatings. Various structures and polymorphs of CaCO3 coatings were obtained by variation of growth conditions (time of fiber incubation in work solution, ultrasonic treatment of this system). Coating homogeneity, CaCO3 polymorphic form, morphology, and CaCO3 mass can be controlled by number of successive stages of fibrous material treatment. Cytotoxicity tests showed that PCL fibers mineralized with CaCO3 did not release substances toxic for cells. SEM images of PCL/CaCO3 scaffolds cultured with cells demonstrate that scaffolds supported cell adhesion and spreading. The presented results show the new technique of controlled PCL scaffold mineralization with vaterite, and an opportunity of using PCL/CaCO3 as scaffolds for tissue engineering.

Язык оригиналаАнглийский
Страницы (с-по)94-103
Число страниц10
ЖурналJournal of Biomedical Materials Research - Part A
Том105
Номер выпуска1
DOI
СостояниеОпубликовано - 1 янв. 2017
Опубликовано для внешнего пользованияДа

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