Translation-Targeting RiPPs and Where to Find Them

Dmitrii Y. Travin, Dmitry Bikmetov, Konstantin Severinov

    Результат исследований: Вклад в журналОбзорная статьярецензирование

    6 Цитирования (Scopus)


    Prokaryotic translation is among the major targets of diverse natural products with antibacterial activity including several classes of clinically relevant antibiotics. In this review, we summarize the information about the structure, biosynthesis, and modes of action of translation inhibiting ribosomally synthesized and post-translationally modified peptides (RiPPs). Azol(in)e-containing RiPPs are known to target translation, and several new compounds inhibiting the ribosome have been characterized recently. We performed a systematic search for biosynthetic gene clusters (BGCs) of azol(in)e-containing RiPPs. This search uncovered several groups of clusters that likely direct the synthesis of novel compounds, some of which may be targeting the ribosome.

    Язык оригиналаАнглийский
    Номер статьи226
    ЖурналFrontiers in Genetics
    СостояниеОпубликовано - 31 мар. 2020


    Подробные сведения о темах исследования «Translation-Targeting RiPPs and Where to Find Them». Вместе они формируют уникальный семантический отпечаток (fingerprint).