The rise and spread of the SARS-CoV-2 AY.122 lineage in Russia

Galya V. Klink, Ksenia R. Safina, Elena Nabieva, Nikita Shvyrev, Sofya Garushyants, Evgeniia Alekseeva, Andrey B. Komissarov, Daria M. Danilenko, Andrei A. Pochtovyi, Elizaveta V. Divisenko, Lyudmila A. Vasilchenko, Elena V. Shidlovskaya, Nadezhda A. Kuznetsova, Anna S. Speranskaya, Andrei E. Samoilov, Alexey D. Neverov, Anfisa V. Popova, Gennady G. Fedonin, Vasiliy G. Akimkin, Dmitry LioznovVladimir A. Gushchin, Vladimir Shchur, Georgii A. Bazykin

Результат исследований: Вклад в журналСтатьярецензирование

5 Цитирования (Scopus)

Аннотация

Delta has outcompeted most preexisting variants of SARS-CoV-2, becoming the globally predominant lineage by mid-2021. Its subsequent evolution has led to the emergence of multiple sublineages, most of which are well-mixed between countries. By contrast, here we show that nearly the entire Delta epidemic in Russia has probably descended from a single import event, or from multiple closely timed imports from a single poorly sampled geographic location. Indeed, over 90 per cent of Delta samples in Russia are characterized by the nsp2:K81N + ORF7a:P45L pair of mutations which is rare outside Russia, putting them in the AY.122 sublineage. The AY.122 lineage was frequent in Russia among Delta samples from the start, and has not increased in frequency in other countries where it has been observed, suggesting that its high prevalence in Russia has probably resulted from a random founder effect rather than a transmission advantage. The apartness of the genetic composition of the Delta epidemic in Russia makes Russia somewhat unusual, although not exceptional, among other countries.

Язык оригиналаАнглийский
Номер статьиveac017
ЖурналVirus Evolution
Том8
Номер выпуска1
DOI
СостояниеОпубликовано - 2022

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