The characterization of PVA/PHY hydrogels for 3D printing fabrication of organ phantoms

E. S. Statnik, E. A. Sorokina, I. I. Larin, Kan Yu, A. I. Salimon, V. Yu Kalyaev, D. D. Zherebtsov, M. Yu Zadorozhnyy, A. M. Korsunsky

    Результат исследований: Вклад в журналСтатья конференциирецензирование

    Аннотация

    Phantoms are widely used substitutes for various types of soft tissues with mechanically and anatomically matching properties. They can be used as advanced tools for training before the surgical manipulation on human organs such as the brain or liver as part of complex operation planning and preparation. We report 3D printing fabrication and characterization of hydrogel composites based on the combination of two biocompatible materials, namely, polyvinyl alcohol (PVA) and phytagel (PHY). The hydrogels were used for the fabrication of brain phantoms in a multistage procedure based around 3D printing. The main goal of this study is to demonstrate the simple, low cost and relatively fast procedure for the creation of hydrogel organ phantoms of high anatomical and mechanical fidelity made from commonly available materials. To this end, three different types of samples were produced to illustrate the flexibility of hydrogel-based 3D printing approach in mimicking the mechanical properties of human organs: brain, lung, and liver soft tissues. The mechanical response was studied using Deben MicroTest 1 kN mechanical testing device and Q800 Dynamic Mechanical Analyser in compression mode. The results reveal close matching of the dynamic non-linear mechanical response of the phantoms to those of the corresponding natural soft tissues.

    Язык оригиналаАнглийский
    Страницы (с-по)1874-1879
    Число страниц6
    ЖурналMaterials Today: Proceedings
    Том33
    DOI
    СостояниеОпубликовано - 2020
    Событие10th International Conference on Key Engineering Materials, ICKEM 2020 - Madrid, Испания
    Продолжительность: 26 мар. 202029 мар. 2020

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