Regulation of gene expression in type II restriction-modification system

M. O. Nagornykh, E. S. Bogdanova, A. S. Protsenko, M. V. Zakharova, A. S. Solonin, K. V. Severinov

Результат исследований: Вклад в журналОбзорная статьярецензирование

9 Цитирования (Scopus)

Аннотация

Type II restriction-modification systems are comprised of a restriction endonuclease and methyltransferase. The enzymes are coded by individual genes and recognize the same DNA sequence. Endonuclease makes a double-stranded break in the recognition site, and methyltransferase covalently modifies the DNA bases within the recognition site, thereby down-regulating endonuclease activity. Coordinated action of these enzymes plays a role of primitive immune system and protects bacterial host cell from the invasion of foreign (for example, viral) DNA. However, uncontrolled expression of the restriction-modification system genes can result in the death of bacterial host cell because of the endonuclease cleavage of host DNA. In the present review, the data on the expression regulation of the type II restriction-modification enzymes are discussed.

Язык оригиналаАнглийский
Страницы (с-по)606-615
Число страниц10
ЖурналGenetika
Том44
Номер выпуска5
СостояниеОпубликовано - мая 2008
Опубликовано для внешнего пользованияДа

Fingerprint

Подробные сведения о темах исследования «Regulation of gene expression in type II restriction-modification system». Вместе они формируют уникальный семантический отпечаток (fingerprint).

Цитировать