Red-Shifted Fluorescent Aminated Derivatives of a Conformationally Locked GFP Chromophore

Mikhail S. Baranov, Kyril M. Solntsev, Nadezhda S. Baleeva, Alexander S. Mishin, Sergey A. Lukyanov, Konstantin A. Lukyanov, Ilia V. Yampolsky

Результат исследований: Вклад в журналСтатьярецензирование

63 Цитирования (Scopus)

Аннотация

A novel class of fluorescent dyes based on conformationally locked GFP chromophore is reported. These dyes are characterized by red-shifted spectra, high fluorescence quantum yields and pH-independence in physiological pH range. The intra- and intermolecular mechanisms of radiationless deactivation of ABDI-BF2 fluorophore by selective structural locking of various conformational degrees of freedom were studied. A unique combination of solvatochromic and lipophilic properties together with "infinite" photostability (due to a dynamic exchange between free and bound dye) makes some of the novel dyes promising bioinspired tools for labeling cellular membranes, lipid drops and other organelles.

Язык оригиналаАнглийский
Страницы (с-по)13234-13241
Число страниц8
ЖурналChemistry - A European Journal
Том20
Номер выпуска41
DOI
СостояниеОпубликовано - 1 окт. 2014
Опубликовано для внешнего пользованияДа

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