Preparation of optically active 1-aminoalkylphosphonic acids by stereoselective enzymatic hydrolysis of racemic N-acylated 1-aminoalkylphosphonic acids

V. A. Solodenko, T. N. Kasheva, V. P. Kukhar, E. V. Kozlova, D. A. Mironenko, V. K. Švedas

    Результат исследований: Вклад в журналСтатьярецензирование

    47 Цитирования (Scopus)

    Аннотация

    N-Phenylacetylated derivatives of 1-aminoalkylphosphonic acids were synthesized and high enantioselectivity of their hydrolysis by penicillin acylase (EC 3.5.1.11) was demonstrated. Stereoselective enzymatic hydrolysis of racemic 1-(N-phenylacetylamino)alkylphosphonic acids was used for preparation of enantiomeric 1-aminoalkylphosphonic acids. The kinetic regularities of penicillin acylase catalyzed hydrolysis were established and the biocatalytic process was optimized to increase the optical purity and the yield of the optically active product.

    Язык оригиналаАнглийский
    Страницы (с-по)3989-3998
    Число страниц10
    ЖурналTetrahedron
    Том47
    Номер выпуска24
    DOI
    СостояниеОпубликовано - 1991

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