N-Pyridyl-Substituted Carboxypiperidine Amides: A New Class of Prokaryote Translation Inhibitors

Ya A. Ivanenkov, E. S. Komarova (Andreyanova), I. A. Osterman, P. V. Sergiev, R. S. Yamidanov, E. V. Deineka, V. A. Terent’ev, G. I. Fil’kov, A. A. Sofronova, A. G. Mazhuga, O. A. Dontsova

    Результат исследований: Вклад в журналСтатьярецензирование

    2 Цитирования (Scopus)

    Аннотация

    High-throughput screening identified a new class of antibacterial compounds based on N-pyridyl-substituted p- and m-carboxypiperidine amides. Constructs with the two reporter genes RFP and Katushka2S allowed the detection of compounds that inhibit protein translation against DNA biosynthesis. Some agents of this class demonstrated antibacterial activity by inhibiting translation. The most promising compound had an MIC of 12 μg/mL. Thus, this class could become a valuable platform for developing new compounds with higher antibacterial activity and selectivity.

    Язык оригиналаАнглийский
    Страницы (с-по)225-229
    Число страниц5
    ЖурналPharmaceutical Chemistry Journal
    Том53
    Номер выпуска3
    DOI
    СостояниеОпубликовано - 15 июн. 2019

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