Mutations in mitochondrial DNA and approaches for their correction

M. V. Patrushev, P. A. Kamenski, I. O. Mazunin

Результат исследований: Вклад в журналОбзорная статьярецензирование

12 Цитирования (Scopus)

Аннотация

Apart from the nucleus, the mitochondrion is the only organelle of an animal cell that contains its own genome. Mitochondrial DNA is much less in size than the nuclear one and codes for only several dozens of biological macromolecules. Nevertheless, mutations in mitochondrial genes often result in the occurrence of serious hereditary neuromuscular diseases. New mitochondrial DNA mutations and their relations to clinical symptoms are continuously reported in the scientific literature. In this review, we summarize existing data about such mutations, and also about contemporary gene therapy approaches that have been developed for their suppression.

Язык оригиналаАнглийский
Страницы (с-по)1151-1160
Число страниц10
ЖурналBiochemistry (Moscow)
Том79
Номер выпуска11
DOI
СостояниеОпубликовано - нояб. 2014
Опубликовано для внешнего пользованияДа

Fingerprint

Подробные сведения о темах исследования «Mutations in mitochondrial DNA and approaches for their correction». Вместе они формируют уникальный семантический отпечаток (fingerprint).

Цитировать