How does tmRNA move through the ribosome?

Pavel V. Ivanov, Maria I. Zvereva, Olga V. Shpanchenko, Olga A. Dontsova, Alexey A. Bogdanov, Galina V. Aglyamova, Valery I. Lim, Yoshika Teraoka, Knud H. Nierhaus

Результат исследований: Вклад в журналСтатьярецензирование

14 Цитирования (Scopus)

Аннотация

To test the structure of tmRNA in solution, cross-linking experiments were performed which showed two sets of cross-links in two different domains of tmRNA. Site-directed mutagenesis was used to search for tmRNA nucleotide bases that might form a functional analogue of a codon-anticodon duplex to be recognized by the ribosomal A-site. We demonstrate that nucleotide residues U85 and A86 from tmRNA are significant for tmRNA function and propose that they are involved in formation of a tmRNA element playing a central role in A-site recognition. These data are discussed in the frame of a hypothetical model that suggests a general scheme for the interaction of tmRNA with the ribosome and explains how it moves through the ribosome.

Язык оригиналаАнглийский
Страницы (с-по)55-59
Число страниц5
ЖурналFEBS Letters
Том514
Номер выпуска1
DOI
СостояниеОпубликовано - 6 мар. 2002
Опубликовано для внешнего пользованияДа

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