Encapsulation of proteins by layer-by-layer adsorption of polyelectrolytes onto protein aggregates: Factors regulating the protein release

Nadejda G. Balabushevitch, Gleb B. Sukhorukov, Natalia A. Moroz, Dmitry V. Volodkin, Natalia I. Larionova, Edwin Donath, Helmuth Mohwald

Результат исследований: Вклад в журналСтатьярецензирование

130 Цитирования (Scopus)

Аннотация

A novel method of protein encapsulation is proposed. Preformed protein aggregates are covered with polyelectrolyte layers by means of layer-by-layer adsorption. The polyelectrolyte membrane prevents protein leakage out of the capsule. Using chymotrypsin as a model enzyme the capsule wall selective permeability was demonstrated for substrates and inhibitors of different molecular weight and solubility.

Язык оригиналаАнглийский
Страницы (с-по)207-213
Число страниц7
ЖурналBiotechnology and Bioengineering
Том76
Номер выпуска3
DOI
СостояниеОпубликовано - 2001
Опубликовано для внешнего пользованияДа

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