Defined picogram dose inclusion and release of macromolecules using polyelectrolyte microcapsules

Christophe Déjugnat, David Haložan, Gleb B. Sukhorukov

Результат исследований: Вклад в журналСтатьярецензирование

70 Цитирования (Scopus)

Аннотация

Reversible pH-induced swelling of (PAH/PSS) polyelectrolyte microcapsules is accompanied by increased porosity, making them permeable to poly(acrylic acid) (PAA) at pH values higher than 11.2. This pH-switchable permeability was used to encapsulate the polyanion in alkaline conditions. Relationship between starting PAA concentration in solution and amount finally being encapsulated has been established and can be used further as calibration curve. A desired amount of encapsulated polymer in the picogram range per capsule can be achieved. The loaded capsules were then used as microreactors by forming a complex between the PAA and Ca2+ ions.

Язык оригиналаАнглийский
Страницы (с-по)961-967
Число страниц7
ЖурналMacromolecular Rapid Communications
Том26
Номер выпуска12
DOI
СостояниеОпубликовано - 16 июн. 2005
Опубликовано для внешнего пользованияДа

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