Yeast Telosome Complex: Components and Their Functions

P. V. Dmitriev, A. V. Petrov, O. A. Dontsova

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)

Abstract

Telomeres are multi-component DNA-protein complexes protecting linear chromosome termini against degradation and fusion. Telomeres and their components are involved in many essential processes: control of cell division number, regulation of transcription, reparation. They are necessary for correct chromosome segregation during cell division. Telomere protein content and DNA length are under control of different factors, such as components of replication and reparation machinery and cell division cycle kinases. Here we discuss the participation of components of yeast telomere (telosome complex) in different cellular processes, telomeric DNA length regulation pathways, and some issues of telosome evolution.

Original languageEnglish
Pages (from-to)718-734
Number of pages17
JournalBiochemistry (Moscow)
Volume68
Issue number7
DOIs
Publication statusPublished - Jul 2003
Externally publishedYes

Keywords

  • Cdc13p
  • Estlp
  • Evolution
  • hRapl
  • KU
  • Raplp
  • RIF
  • SIR
  • Tbflp
  • Telomerase
  • Telomere
  • Telosome complex
  • TRF

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