Xenogeneic Regulation of the Bacterial Transcription Machinery

Aline Tabib-Salazar, Nancy Mulvenna, Konstantin Severinov, Steve J. Matthews, Sivaramesh Wigneshweraraj

    Research output: Contribution to journalReview articlepeer-review

    12 Citations (Scopus)


    The parasitic life cycle of viruses involves the obligatory subversion of the host's macromolecular processes for efficient viral progeny production. Viruses that infect bacteria, bacteriophages (phages), are no exception and have evolved sophisticated ways to control essential biosynthetic machineries of their bacterial prey to benefit phage development. The xenogeneic regulation of bacterial cell function is a poorly understood area of bacteriology. The activity of the bacterial transcription machinery, the RNA polymerase (RNAP), is often regulated by a variety of mechanisms involving small phage-encoded proteins. In this review, we provide a brief overview of known phage proteins that interact with the bacterial RNAP and compare how two prototypical phages of Escherichia coli, T4 and T7, use small proteins to “puppeteer” the bacterial RNAP to ensure a successful infection.

    Original languageEnglish
    Pages (from-to)4078-4092
    Number of pages15
    JournalJournal of Molecular Biology
    Issue number20
    Publication statusPublished - 20 Sep 2019


    • bacteriophage
    • Escherichia coli
    • RNA polymerase
    • T4 phage
    • T7 phage


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