What do we know about ribosomal RNA methylation in Escherichia coli?

O. V. Sergeeva, A. A. Bogdanov, P. V. Sergiev

    Research output: Contribution to journalReview articlepeer-review

    38 Citations (Scopus)

    Abstract

    A ribosome is a ribonucleoprotein that performs the synthesis of proteins. Ribosomal RNA of all organisms includes a number of modified nucleotides, such as base or ribose methylated and pseudouridines. Methylated nucleotides are highly conserved in bacteria and some even universally. In this review we discuss available data on a set of modification sites in the most studied bacteria, Escherichia coli. While most rRNA modification enzymes are known for this organism, the function of the modified nucleotides is rarely identified.

    Original languageEnglish
    Pages (from-to)110-118
    Number of pages9
    JournalBiochimie
    Volume117
    DOIs
    Publication statusPublished - 1 Oct 2015

    Keywords

    • Escherichia coli
    • Modification
    • Ribosome
    • Ribosome assembly
    • RNA methyltransferase
    • rRNA

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