Water-soluble fullerene derivatives: the inhibition effect on polyol pathway enzymes and antidiabetic potential on high-fat diet/low-dose streptozotocin-induced diabetes in rats

Yuliya V. Soldatova, David A. Areshidze, Alexander V. Zhilenkov, Olga A. Kraevaya, Alexander S. Peregudov, Daria A. Poletaeva, Irina I. Faingold, Pavel A. Troshin, Raisa A. Kotelnikova

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1 Citation (Scopus)

Abstract

Water-soluble pentaamino acid fullerene (C60) derivatives (PFD) are promising nanomaterials with a wide range of biomedical applications. The present study has shown that PFD-7 competitively inhibits aldose reductase and sorbitol dehydrogenase, enzymes of the polyol pathway of glucose metabolism, which are known to be associated with diabetic complications. Treatment with PFD-7 was associated with a decrease in blood glucose level and improvement pancreas and liver morphology in rats with type 2 diabetes mellitus (induced by a high fat diet and streptozotocin). The data obtained indicating the ability of pentaamino acid fullerene (C60) derivatives to exhibit a pronounced antidiabetic effect. Thus, PFD-7 may be considered to contribute significantly to treatment of type 2 diabetes mellitus and diabetic complications. Graphical abstract: [Figure not available: see fulltext.].

Original languageEnglish
Article number202
JournalJournal of Nanoparticle Research
Volume23
Issue number9
DOIs
Publication statusPublished - Sep 2021
Externally publishedYes

Keywords

  • Aldose reductase
  • Diabetic rats
  • Fullerene derivatives
  • High-fat diet
  • Polyol pathway
  • Streptozotocin

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