Water-Soluble Anionic C60-Fullerene Derivatives as Antidotes for HG(II) Ions in Tests on Escherichia Coli Cells

A. V. Zhilenkov, E. A. Khakina, P. A. Troshin, I. F. Karimov, D. G. Deryabin

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Three water-soluble C60-fullerene derivatives functionalized by anionic adducts of various chemical compositions and structures were prepared in highly specific reactions of chlorofullerene C60Cl6. Hybrid metal-organic complexes formed and aggregated in several instances in aqueous solution in the presence of stoichiometric (1:1 by moles) amounts of synthesized C60-fullerene derivatives and Hg(II) ions. The bioavailability of Hg(II) ions for Escherichia coli cells was reduced by such a reaction and manifested as decreased toxicity for strain E. coli K12 TG1 pF1 or weakened protective reactions of strain E. coli K12 MG1655 pMerA'::lux. The most pronounced protective effect was recorded for the C60-fullerene derivative functionalized by S-containing adducts of general formula –S(CH2)10CO2K with antidote activity comparable with that of the pharmacopoeial preparation Unithiol.

Original languageEnglish
Pages (from-to)312-317
Number of pages6
JournalPharmaceutical Chemistry Journal
Volume53
Issue number4
DOIs
Publication statusPublished - 15 Jul 2019

Keywords

  • bioavailability
  • C-fullerene
  • Escherichia coli
  • HgCl

Fingerprint

Dive into the research topics of 'Water-Soluble Anionic C60-Fullerene Derivatives as Antidotes for HG(II) Ions in Tests on Escherichia Coli Cells'. Together they form a unique fingerprint.

Cite this