Uptake of colloidal polyelectrolyte-coated particles and polyelectrolyte multilayer capsules by living cells

Alumdena Muñoz Javier, Oliver Kreft, Maximilian Semmling, Susanne Kempter, Andre G. Skirtach, Oliver T. Bruns, Pablo Del Pino, Mathieu F. Bedard, Joachim Rädler, Josef Käs, Christian Plank, Gleb B. Sukhorukov, Wolfgang J. Parak

Research output: Contribution to journalArticlepeer-review

154 Citations (Scopus)

Abstract

Uptake of colloidal polyelectrolyte-coated particles and polyelectrolyte multilayer capsules has been demonstrated by living cells. The capsules for this study were prepared by poly(diallyldimethylammoniumchloride) (PDMAC) and poly(styrene sulfonate) (PSS) on SiO2. SiO2 template cores were used because of their negative charge. It was observed during the study that SiO2 templates dissolved in hydrofluoric acid after the formation of capsule-shell. The study also found that heat treatment can be used for stable encapsulation of materials inside the microcapsuels made on SiO 2. It was also found that calcium carbonate microparticles can provide a loading capacity for biological materials. The study used a confocal laser scanning microscopy (CLSM) to examine the capsule incorporation by the cells.

Original languageEnglish
Pages (from-to)4281-4287
Number of pages7
JournalAdvanced Materials
Volume20
Issue number22
DOIs
Publication statusPublished - 18 Nov 2008
Externally publishedYes

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