Ultrasonically induced opening of polyelectrolyte microcontainers

Dmitry G. Shchukin, Dmitry A. Gorin, Helmuth Möhwald

Research output: Contribution to journalArticlepeer-review

171 Citations (Scopus)

Abstract

The effect of ultrasonic treatments of different intensity and duration on the integrity and permeability of polyelectrolyte capsules was investigated both in poly(allylamine)/poly(styrene sulfonate) and Fe3O 4/poly(allylamine)/poly(styrene sulfonate) polyelectrolyte capsules. Ultrasonic treatment of polyelectrolyte capsules induces the destruction of the polyelectrolyte shell and the release of the encapsulated material even at short (5 s) sonification times. The presence of magnetite nanoparticles significantly improves the efficiency of the ultrasonically stimulated release of the encapsulated compounds and enables magnetically controlled delivery to the desired site before ultrasonic treatment. Release of the encapsulated compound induced at ultrasonic power comparable to those of ultrasonic generators applied in medicine, demonstrating practical application of the ultrasonically triggered capsule opening in medicine.

Original languageEnglish
Pages (from-to)7400-7404
Number of pages5
JournalLangmuir
Volume22
Issue number17
DOIs
Publication statusPublished - 15 Aug 2006
Externally publishedYes

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