trans-translation: The main participants and the role in cell life

O. V. Shpanchenko, P. V. Ivanov, M. E. Zvereva, A. A. Bogdanov, O. A. Dontsova

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


trans-Translation is the unique process of synthesizing a single polypeptide chain from both mRNA and the coding region of transport-messenger RNA (tmRNA). It is necessary for cell vital activity in the changing environment. New data on the main participants of trans-translation, conditions under which it occurs, and its role in the cell are reviewed. The possible role of tmRNA in translation quality control is discussed.

Original languageEnglish
Pages (from-to)777-788
Number of pages12
JournalMolecular Biology
Issue number5
Publication statusPublished - Sep 2004
Externally publishedYes


  • 10Sa RNA
  • prokaryotes
  • protein biosynthesis
  • ribosome
  • ssrA
  • tmRNA
  • trans-translation
  • translation termination


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