Toward a whole-body neuroprosthetic

Mikhail A. Lebedev, Miguel A.L. Nicolelis

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

30 Citations (Scopus)


Brain-machine interfaces (BMIs) hold promise for the restoration of body mobility in patients suffering from devastating motor deficits caused by brain injury, neurological diseases, and limb loss. Considerable progress has been achieved in BMIs that enact arm movements, and initial work has been done on BMIs for lower limb and trunk control. These developments put Duke University Center for Neuroengineering in the position to develop the first BMI for whole-body control. This whole-body BMI will incorporate very large-scale brain recordings, advanced decoding algorithms, artificial sensory feedback based on electrical stimulation of somatosensory areas, virtual environment representations, and a whole-body exoskeleton. This system will be first tested in nonhuman primates and then transferred to clinical trials in humans.

Original languageEnglish
Title of host publicationProgress in Brain Research
PublisherElsevier B.V.
Number of pages14
Publication statusPublished - 2011
Externally publishedYes

Publication series

NameProgress in Brain Research
ISSN (Print)0079-6123
ISSN (Electronic)1875-7855


  • Active touch
  • Artificial sensation
  • Balance
  • Bidirectional brain-machine interface
  • Bimanual
  • Brain-machine interface
  • Brain-machine-brain interface
  • Exoskeleton
  • Functional electrical stimulation
  • Intracortical microstimulation
  • Locomotion
  • Multielectrode implant
  • Neuroprosthetic feedback
  • Posture
  • Primary motor cortex
  • Primary somatosensory cortex


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