The Mod(mdg4) component of the Su(Hw) insulator inserted in the P transposon can repress its mobility in Drosophila melanogaster

Marina Karakozova, Ekaterina Savitskaya, Larisa Melnikova, Aleksandr Parshikov, Pavel Georgiev

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Transposable element P of Drosophila melanogaster is one of the best-characterized eukaryotic transposons. Successful transposition requires the interaction between transposase complexes at both termini of the P element. Here we found that insertion of one or two copies of the Su(Hw) insulator in the P transposon reduces the frequency of its transposition. Inactivation of a Mod(mdg4) component of the Su(Hw) insulator suppresses the insulator effect. Thus, the Su(Hw) insulator can modulate interactions between transposase complexes bound to the ends of the P transposon in germ cells.

Original languageEnglish
Pages (from-to)1275-1280
Number of pages6
JournalGenetics
Volume167
Issue number3
DOIs
Publication statusPublished - Jul 2004
Externally publishedYes

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