The Human Proteome Organization Chromosome 6 Consortium: Integrating chromosome-centric and biology/disease driven strategies

C. H. Borchers, J. Kast, L. J. Foster, K. W.M. Siu, C. M. Overall, T. A. Binkowski, W. H. Hildebrand, A. Scherer, M. Mansoor, P. A. Keown

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)

Abstract

The Human Proteome Project (HPP) is designed to generate a comprehensive map of the protein-based molecular architecture of the human body, to provide a resource to help elucidate biological and molecular function, and to advance diagnosis and treatment of diseases. Within this framework, the chromosome-based HPP (C-HPP) has allocated responsibility for mapping individual chromosomes by country or region, while the biology/disease HPP (B/D-HPP) coordinates these teams in cross-functional disease-based groups. Chromosome 6 (Ch6) provides an excellent model for integration of these two tasks. This metacentric chromosome has a complement of 1002-1034 genes that code for known, novel or putative proteins. Ch6 is functionally associated with more than 120 major human diseases, many with high population prevalence, devastating clinical impact and profound societal consequences. The unique combination of genomic, proteomic, metabolomic, phenomic and health services data being drawn together within the Ch6 program has enormous potential to advance personalized medicine by promoting robust biomarkers, subunit vaccines and new drug targets. The strong liaison between the clinical and laboratory teams, and the structured framework for technology transfer and health policy decisions within Canada will increase the speed and efficacy of this transition, and the value of this translational research.

Original languageEnglish
Pages (from-to)60-67
Number of pages8
JournalJournal of Proteomics
Volume100
DOIs
Publication statusPublished - 4 Apr 2014
Externally publishedYes

Keywords

  • Chromosome 6
  • Human Proteome Project
  • Proteomics

Fingerprint

Dive into the research topics of 'The Human Proteome Organization Chromosome 6 Consortium: Integrating chromosome-centric and biology/disease driven strategies'. Together they form a unique fingerprint.

Cite this