The effect of space flight on the protein composition of the exhaled breath condensate of cosmonauts

K. Yu Fedorchenko, A. M. Ryabokon’, A. S. Kononikhin, S. I. Mitrofanov, E. A. Mikhant’eva, A. I. Spasskii, I. R. Sukhodolov, I. A. Popov, A. V. Polyakov, I. M. Larina, E. N. Nikolaev, S. D. Varfolomeev

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    As a part of development of medicine for extreme situations, we determined, for the first time, the protein composition of the exhaled breath condensate (EBC) of cosmonauts before and after long-lasting orbital flights on the International Space Station (ISS). The analysis was performed by electrospray ionization ion cyclotron resonance mass spectrometry. The pattern of variation of the protein composition of the exhaled air during preflight preparation, at the time of landing, and seven days after landing was elucidated. Forty-four proteins, which appeared in the exhaled breath condensate of the cosmonauts after a long orbital flight and landing and were absent before the flight, were detected. These proteins included the immune response proteins, indicating cell and blood vessel damage. In some cases, a temporary appearance of cancer markers was noted.

    Original languageEnglish
    Pages (from-to)2745-2750
    Number of pages6
    JournalRussian Chemical Bulletin
    Volume65
    Issue number11
    DOIs
    Publication statusPublished - 1 Nov 2016

    Keywords

    • cosmonauts
    • exhaled breath condensate
    • GC/MS
    • protein composition of exhaled breath condensate

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