The Common Partner of Several Methyltransferases Modifying the Components of The Eukaryotic Translation Apparatus

E. N. Vasilieva, I. G. Laptev, P. V. Sergiev, O. A. Dontsova

    Research output: Contribution to journalReview articlepeer-review

    Abstract

    Abstract: TRM112 is necessary for the activation and stability of several methyltransferases involved in the modification of various components of the translation apparatus. This unique protein is a partner for enzymes that methylate tRNA, rRNA, and the translation termination factor. Here we review the structural and functional features of the TRM112 complexes with methyltransferases and provide, where possible, information on their significance.

    Original languageEnglish
    Pages (from-to)846-853
    Number of pages8
    JournalMolecular Biology
    Volume52
    Issue number6
    DOIs
    Publication statusPublished - 1 Nov 2018

    Keywords

    • methylation
    • methyltransferase
    • ribosome assembly
    • rRNA
    • translation
    • translation termination factor
    • tRNA

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