TRM112 is necessary for the activation and stability of several methyltransferases involved in the modification of various components of the translation apparatus. This unique protein is a partner for enzymes that methylate tRNA, rRNA, and the translation termination factor. Here we review the structural and functional features of the TRM112 complexes with methyltransferases and provide, where possible, information on their significance.
- ribosome assembly
- translation termination factor