The chromatin structure of Dictyostelium discoideum

Olga Tsoy, Aleksandra Galitsyna, Ekaterina Khrameeva, Sergey Ulianov, Mikhail Gelfand, Sergey Razin

    Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

    Abstract

    The principles of three-dimensional organization of chromatin are known for only few model organisms. Here we describe the structure of chromatin and gene expression in the slime mold - Dictyostelium discoideum, and its changes during the life cycle. The slime mold mainly exists as a unicellular amoeba, but during starvation the amoebae start to aggregate and form a multicellular fruit body for reproduction. The genome (34,21 Mb, 6 chromosomes) of D. discoideum is unusual [1]: it has a high gene density, very low GC-content (22,43%) and numerous repeats.

    Original languageEnglish
    Title of host publicationProceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018
    EditorsHarald Schmidt, David Griol, Haiying Wang, Jan Baumbach, Huiru Zheng, Zoraida Callejas, Xiaohua Hu, Julie Dickerson, Le Zhang
    PublisherInstitute of Electrical and Electronics Engineers Inc.
    Number of pages1
    ISBN (Electronic)9781538654880
    DOIs
    Publication statusPublished - 21 Jan 2019
    Event2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018 - Madrid, Spain
    Duration: 3 Dec 20186 Dec 2018

    Publication series

    NameProceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018

    Conference

    Conference2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018
    Country/TerritorySpain
    CityMadrid
    Period3/12/186/12/18

    Keywords

    • chromatin
    • loops
    • topologically associated domains

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