Tetrahedral DNA conjugates from pentaerythritol-based polyazides

Anna I. Ponomarenko, Vladimir A. Brylev, Ksenia A. Sapozhnikova, Alexey V. Ustinov, Igor A. Prokhorenko, Timofei S. Zatsepin, Vladimir A. Korshun

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)

    Abstract

    Branching points in DNA nanostructures are usually 3- or 4-way junctions maintained by Watson-Crick non-covalent interactions. However, covalently bound DNA stars could improve the diversity, strength and integrity of DNA nanoscale constructions. We report here the convenient synthesis of 3- and 4-fold pentaerythritol-based azides and their use for the assembly of branched conjugates containing the same or different oligonucleotides (ODNs) and/or fluorescent dyes by stoichiometry controlled copper (I) catalyzed azide alkyne cycloaddition (CuAAC) functionalization.

    Original languageEnglish
    Pages (from-to)2386-2391
    Number of pages6
    JournalTetrahedron
    Volume72
    Issue number19
    DOIs
    Publication statusPublished - 12 May 2016

    Keywords

    • Branched DNA
    • Click reaction
    • Conjugates
    • Fluorescent dyes
    • Oligonucleotides

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