Telomerase level versus spliced hTERT-specific RNA forms in cervical carcinoma

M. D. Fedorova, A. A. Petrenko, D. A. Skvortsova, L. S. Pavlova, M. E. Zvereva, M. P. Rubtsova, O. A. Dontsova, F. L. Kiselev

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Abstract

An attempt was made to identify molecular markers of different clinical stages of cervical carcinoma caused by papilloma virus (HPV). Presence of viral genome, telomerase level and expression of a gene, which coded the catalytic activity of that enzyme (hTERT), were assayed in 89 patients. HPV (type 16) genome harboring tumors were detected in 73% which was in conformity with the literature and our own data. Telomerase was identified (TRAP) in all tumors and tumor cells cultured in vitro. hTERT-specific RNA was found in all tumor samples, however, increase in its expression was insignificant. As far as the three markers are concerned, no significant differences between clinical stages of tumor were reported.

Original languageEnglish
Pages (from-to)29-35
Number of pages7
JournalVoprosy Onkologii
Volume56
Issue number1
Publication statusPublished - 2010
Externally publishedYes

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