Synthesis of modified nucleotide building blocks containing electrophilic groups in the 2′-position

Anna V. Kachalova, Timofei S. Zatsepin, Elena A. Romanova, Dmitry A. Stetsenko, Michael J. Gait, Tatiana S. Oretskaya

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Chemical syntheses of 2′-O-(allyloxycarbonyl)methyladenosine, 2′-0-(methoxycarbonyl)methyladenosine and 2′-O-(2,3-dibenzoyloxy)propyluridine 3′-2-cyanoethyl-N,N-diisopropyl phosphoramidite building blocks are described. These monomers were used successfully to incorporate carboxylic acid, 1,2-diol and aldehyde functionalities into synthetic oligonucleotides.

Original languageEnglish
Pages (from-to)1693-1707
Number of pages15
JournalNucleosides, Nucleotides and Nucleic Acids
Volume19
Issue number10-12
DOIs
Publication statusPublished - 2000
Externally publishedYes

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