Synthesis of 2′-modified oligonucleotides containing aldehyde or ethylenediamine groups

T. S. Zatsepin, E. A. Romanova, D. A. Stetsenko, M. J. Gait, T. S. Oretskaya

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Oligonucleotides carrying 2′-aldehyde groups were synthesized and coupled to peptides containing an N-terminal cysteine, aminooxy or hydrazide group to give peptide-oligonucleotide conjugates in good yield. The synthesis of a novel phosphoramidite reagent for the incorporation of 2′ -O-(2,3-diaminopropyl)uridine into oligonucleotides was also described. Resultant 2′-diaminooligonucleotides may be useful intermediates in further peptide conjugation studies.

Original languageEnglish
Pages (from-to)1383-1385
Number of pages3
JournalNucleosides, Nucleotides and Nucleic Acids
Volume22
Issue number5-8
DOIs
Publication statusPublished - 2003
Externally publishedYes

Keywords

  • Aldehyde
  • Conjugate
  • Oligonucleotide
  • Peptide
  • Phosphoramidite

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