Synthesis and applications of oligonucleotide-carbohydrate conjugates

Timofei S. Zatsepin, Tatiana S. Oretskaya

Research output: Contribution to journalReview articlepeer-review

56 Citations (Scopus)

Abstract

Nowadays, oligonucleotide-carbohydrate conjugates are used in antisense biotechnology and in the study of glycosylated DNA functioning in vitro. The application of mono- and disaccharide phosphoramidites, solidphase supports with immobilized carbohydrates, glycosylated nucleoside phosphoramidites, and postsynthetic conjugation of reactive sugar derivatives with oligonucleotides for preparation of oligonucleotide-carbohydrate conjugates have been systematically studied. The advantages and disadvantages of these approaches are considered. Possible strategies for synthesis of glycoclusters with different topologies conjugated to DNA are discussed. Applications of oligonucleotide- carbohydrate conjugates are highlighted. Studies of interactions of glycosylated oligonucleotides with proteins and effective cell-specific delivery of oligonucleotide-carbohydrate conjugates are discussed.

Original languageEnglish
Pages (from-to)1401-1417
Number of pages17
JournalChemistry and Biodiversity
Volume1
Issue number10
DOIs
Publication statusPublished - 2004
Externally publishedYes

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