Synthesis and antiviral activity of highly water-soluble polycarboxylic derivatives of [70]fullerene

Alexey B. Kornev, Alexander S. Peregudov, Vyacheslav M. Martynenko, Jan Balzarini, Bart Hoorelbeke, Pavel A. Troshin

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)

Abstract

We report here a facile preparation of highly water-soluble derivatives C70[p-C6H4(CH2)nCOOH] 8 (n = 2, 3) starting from readily available chlorinated [70]fullerene precursors C70Cl8 and C70Cl 10. The synthesized fullerene derivatives showed pronounced antiviral activity in vitro, particularly against human immunodeficiency virus (HIV) and influenza A virus (subtypes H1N1 and H3N2).

Original languageEnglish
Pages (from-to)8298-8300
Number of pages3
JournalChemical Communications
Volume47
Issue number29
DOIs
Publication statusPublished - 7 Aug 2011
Externally publishedYes

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