Synthesis and antibacterial activity of hybrid supramolecular complexes based on tetracycline/doxycycline and water-soluble C60-fullerene derivatives

A. V. Zhilenkov, E. A. Khakina, P. A. Troshin, K. S. Inchagova, D. G. Deryabin

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Water-soluble pentasubstituted anionic and cationic C60 -fullerene derivatives were synthesized in highly selective reactions of chlorofullerene C60 Cl 6 with captopril and an aliphatic amine. Hybrid supramolecular complexes of the functionalized C 60 -fullerene derivatives and tetracycline antibiotics (in a stoichiometric 1:1 mole ratio) with polymodal hydrodynamic-radius distributions were synthesized in aqueous solution as nano-sized micelles and vesicles. Hybrid complexes of the antibiotics and cationic amino-C60 -fullerene derivatives exhibited synergic antibacterial effects that were more pronounced against a tetracycline-resistant Escherichia coli strain (carrier of the TcR gene).

Original languageEnglish
Pages (from-to)637-641
Number of pages5
JournalPharmaceutical Chemistry Journal
Volume50
Issue number10
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • Antibacterial activity
  • C -fullerene
  • Hybrid complex
  • Tetracycline

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