Sustained release properties of polyelectrolyte multilayer capsules

Alexei A. Antipov, Gleb B. Sukhorukov, Edwin Donath, Helmuth Möhwald

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354 Citations (Scopus)


Layer-by-layer (LbL) assembly of oppositely charged polyelectrolytes was used to coat fluorescein particles. These particles, with a size of 4-9 μm, were prepared by precipitation of fluorescein at pH 2. Polystyrensulfonate (PSS) and polyallylamine (PAH) were used to form a polyelectrolyte shell on the fluorescein core. The permeation of fluorescein molecules through the polyelectrolyte shell during core dissolution was monitored at pH 8 by the increasing fluorescence intensity as a result of dequenching. The number of polyelectrolyte layers sufficient to sustain fluorescein release was found to be 8-10. Increasing the number of layers prolonged the core dissolution time for minutes. The permeability of polyelectrolyte multilayers of the thickness of 20 nm for fluorescein is about 10-9 m/s. The features of the release profile and possible applications of the LbL method for shell formation in order to control release properties for entrapped materials are outlined.

Original languageEnglish
Pages (from-to)2281-2284
Number of pages4
JournalJournal of Physical Chemistry B
Issue number12
Publication statusPublished - 29 Mar 2001
Externally publishedYes


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