Structure and function of tmRNA (10Sa RNA)

M. E. Zvereva, O. V. Shpanchenko, O. A. Dontsova, A. A. Bogdanov

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Modern data on the structure and function of transport/messenger (tm) RNA are reviewed. This stable RNA is involved in releasing ribosomes that are unable to complete protein synthesis on mRNA lacking the stop codon. The resulting abnormal proteins are rapidly degraded by specific proteases, which recognize a signal peptide encoded by the template region of tmRNA. The discovery of trans-translation has caused a particular interest in structural and functional studies of tmRNA.

Original languageEnglish
Pages (from-to)927-933
Number of pages7
JournalMolecular Biology
Volume34
Issue number6
DOIs
Publication statusPublished - 2000
Externally publishedYes

Keywords

  • Aminoacylation
  • Degradation
  • Eubacteria
  • RNA
  • Translation

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