Structure and antibacterial activity (mediated by the SOS response) of spiropiperidinium salts obtained by cyclization of Mannich bases of arylaliphatic 1,5-diketones

Aleksey V. Bukreev, Taisia I. Akimova, Ilya Osterman, Anna N. Shakhtina, Yuliya V. Khudyakova, Andrey V. Gerasimenko, Petr V. Sergiev, Olga Dontsova, Pavel I. Deryabin, Vera B. Kolycheva

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

[Figure not available: see fulltext.] New derivatives of 3,5-dibenzoylspiropiperidinium salts were obtained by the previously developed method of cyclization of Mannich methylidene monobases of arylaliphatic 1,5-diketones and their antibacterial activity was studied. The structure of one of the salts was determined by X-ray structural analysis. The study of the mechanism of action using the pDualrep2 reporter system showed that some compounds cause the SOS response in the bacterial cell.

Original languageEnglish
Pages (from-to)756-762
Number of pages7
JournalChemistry of Heterocyclic Compounds
Volume56
Issue number6
DOIs
Publication statusPublished - 1 Jun 2020

Keywords

  • 1,5-diketones
  • antibacterial activity
  • Mannich bases
  • quaternary ammonium salts
  • SOS response
  • spiropiperidinium salts

Fingerprint

Dive into the research topics of 'Structure and antibacterial activity (mediated by the SOS response) of spiropiperidinium salts obtained by cyclization of Mannich bases of arylaliphatic 1,5-diketones'. Together they form a unique fingerprint.

Cite this