Structural Investigation of Biomacromolecules Using Ultrahigh-Resolution Mass Spectrometry and Isotope Exchange

Y. I. Kostyukevich, A. S. Kononikhin, I. A. Popov, E. N. Nikolaev

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)

    Abstract

    We present a new analysis methodology for arbitrary complex molecular systems using ultrahigh-resolution mass spectrometry and isotope exchange. The kinetics of the hydrogen–deuterium exchange reaction is described for large biomacromolecules. The possible applications of the proposed methodology for the analysis of linear oligosaccharides, proteins, and molecular ensemble of humic acids are discussed.

    Original languageEnglish
    Pages (from-to)599-604
    Number of pages6
    JournalRussian Journal of Physical Chemistry B
    Volume12
    Issue number4
    DOIs
    Publication statusPublished - 1 Jul 2018

    Keywords

    • isotope exchange
    • mass spectrometry
    • ultrahigh resolution

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