Structural and evolutionary insights into ribosomal RNA methylation

Petr V. Sergiev, Nikolay A. Aleksashin, Anastasia A. Chugunova, Yury S. Polikanov, Olga A. Dontsova

    Research output: Contribution to journalReview articlepeer-review

    79 Citations (Scopus)


    Methylation of nucleotides in ribosomal RNAs (rRNAs) is a ubiquitous feature that occurs in all living organisms. Identification of all enzymes responsible for rRNA methylation, as well as mapping of all modified rRNA residues, is now complete for a number of model species, such as Escherichia coli and Saccharomyces cerevisiae. Recent high-resolution structures of bacterial ribosomes provided the first direct visualization of methylated nucleotides. The structures of ribosomes from various organisms and organelles have also lately become available, enabling comparative structure-based analysis of rRNA methylation sites in various taxonomic groups. In addition to the conserved core of modified residues in ribosomes from the majority of studied organisms, structural analysis points to the functional roles of some of the rRNA methylations, which are discussed in this Review in an evolutionary context.

    Original languageEnglish
    Pages (from-to)226-235
    Number of pages10
    JournalNature Chemical Biology
    Issue number3
    Publication statusPublished - 14 Feb 2018


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