Stimuli-responsive multilayered hybrid nanoparticle/polyelectrolyte capsules

Bruno G. De Geest, Andrei G. Skirtach, Thomas R.M. De Beer, Gleb B. Sukhorukov, Lieven Bracke, Willy R.G. Baeyens, Joseph Demeester, Stefaan C. De Smedt

Research output: Contribution to journalArticlepeer-review

64 Citations (Scopus)


Gold nanoparticles (AuNP) with carboxyl groups on their surface were used in combination with PAH for the layer-by-layer coating of CaCO 3 microparticles, followed by the dissolution of the CaCO3 core. SEM, TEM, and confocal microscopy are used to characterize the hybrid nanoparticles/polyelectrolyte capsules. As the AuNP have carboxyl groups on their surface, their charge density is pH dependent; therefore, the capsules exhibit a pH- dependent swelling and can be deconstructed both at low and high pH. By covalent cross-linking of the carboxyl groups of the Au NP and the amino groups of the PAH, it is possible to suppress the pH-responsive behavior. AuNP are used as activation centers using IR light and this ability is used to release encapsulated material from the nanoparticles/polyelectrolyte capsules as well as for the enhancement of detection and imaging of such capsules by Raman microspectrosopy.

Original languageEnglish
Pages (from-to)88-95
Number of pages8
JournalMacromolecular Rapid Communications
Issue number1
Publication statusPublished - 5 Jan 2007
Externally publishedYes


  • Layer-by-layer
  • Micro encapsulation
  • Nanoparticles
  • Polyelectrolytes
  • Stimuli-responsive


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