Steroid promiscuity: Diversity of enzyme action

Richard Lathe, Yuri Kotelevtsev, J. Ian Mason

    Research output: Contribution to journalEditorial

    10 Citations (Scopus)

    Abstract

    This Special Issue on the topic of Steroid and Sterol Signaling: Promiscuity and Diversity, dwells on the growing realization that the ‘one ligand, one binding site’ and ‘one enzyme, one reaction’ concepts are out of date. Focusing on cytochromes P450 (CYP), hydroxysteroid dehydrogenases (HSDs), and related enzymes, the Special Issue highlights that a single enzyme can bind to diverse substrates, and in different conformations, and can catalyze multiple different conversions (and in different directions), thereby, generating an unexpectedly wide spectrum of ligands that can have subtly different biological actions. This article is part of a Special Issue entitled ‘Steroid/Sterol Signaling’.

    Original languageEnglish
    Pages (from-to)1-2
    Number of pages2
    JournalJournal of Steroid Biochemistry and Molecular Biology
    Volume151
    DOIs
    Publication statusPublished - 2015

    Keywords

    • Promiscuity
    • Steroid

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