Spaceflight induced changes in the human proteome

Alexey S. Kononikhin, Natalia L. Starodubtseva, Lyudmila Kh Pastushkova, Daria N. Kashirina, Kristina Yu Fedorchenko, Alexander G. Brhozovsky, Igor A. Popov, Irina M. Larina, Evgeny N. Nikolaev

    Research output: Contribution to journalReview articlepeer-review

    22 Citations (Scopus)


    Introduction: Spaceflight is one of the most extreme conditions encountered by humans: Individuals are exposed to radiation, microgravity, hypodynamia, and will experience isolation. A better understanding of the molecular processes induced by these factors may allow us to develop personalized countermeasures to minimize risks to astronauts. Areas covered: This review is a summary of literature searches from PubMed, NASA, Roskosmos and the authors’ research experiences and opinions. The review covers the available proteomic data on the effects of spaceflight factors on the human body, including both real space missions and ground-based model experiments. Expert commentary: Overall, the authors believe that the present background, methodology and equipment improvements will enhance spaceflight safety and support accumulation of new knowledge on how organisms adapt to extreme conditions.

    Original languageEnglish
    Pages (from-to)15-29
    Number of pages15
    JournalExpert Review of Proteomics
    Issue number1
    Publication statusPublished - 2 Jan 2017


    • bed rest study
    • dry immersion
    • extreme conditions
    • human proteome
    • MARS 500
    • microgravity
    • proteomics
    • Spaceflight
    • spaceflight simulation


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