Sonication mediated covalent cross-linking of DNA to single-walled carbon nanotubes

Bridget D. Dolash, Roya R. Lahiji, Dmitry Y. Zemlyanov, Vladimir P. Drachev, Ronald Reifenberger, Donald E. Bergstrom

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Sonication with nucleic acids has become a standard method for obtaining aqueous dispersions of carbon nanotubes. On the basis of theoretical studies and scanning probe microscopy (SPM) imaging a widely accepted model for DNA association with SWCNT is one in which the DNA binds through non-covalent π-stacking and hydrophobic interactions. Following the standard procedures established by others to prepare DNA associated single-wall carbon nanotubes (SWCNT), we have determined that sonication generates radical intermediates then form covalent anchors between the DNA and SWCNT. In light of this finding, results from studies on DNA associated carbon nanotubes, need to be more carefully interpreted.

Original languageEnglish
Pages (from-to)11-19
Number of pages9
JournalChemical Physics
Volume413
DOIs
Publication statusPublished - 21 Feb 2013
Externally publishedYes

Keywords

  • Carbon nanotubes
  • Covalent cross-linking
  • DNA
  • Free radicals
  • Sonication

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