Semicontinuous silver films for protein sensing with SERS

Vladimir P. Drachev, Mark Thoreson, Eldar Khaliullin, Andrey K. Sarychev, Dongmao Zhang, Dor Ben-Amotz, Vladimir M. Shalaev

Research output: Contribution to journalConference articlepeer-review

12 Citations (Scopus)

Abstract

Semicontinuous silver films for protein sensing with surface enhanced Raman scattering (SERS) was discussed. An insulin density surface density as low as 80 fmol/mm2 and 25 amol in a probed area was detected. The insulin spots were deposited on a quartz substrate at different insulin concentrations (10-200 μM) and volumes in the drop (5-10 μL). Increasing the thickness of an insulin layer above 10 μM did not change the signal. The measured average enhancement factor of the SERS-active silver structure was also found to exceed 106.

Original languageEnglish
Pages (from-to)76-81
Number of pages6
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5221
DOIs
Publication statusPublished - 2003
Externally publishedYes
EventPlasmonics: Metallic Nanostuctures and Their Optical Properties - San Diego, CA, United States
Duration: 3 Aug 20035 Aug 2003

Keywords

  • Human insulin
  • Semicontinuous metal films
  • SERS of proteins

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