Secretome of Cultured Human Endothelial Cells in Simulated Microgravity

D. N. Kashirina, A. S. Kononikhin, I. M. Larina, L. B. Buravkova

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The secretome of human umbilical vein endothelial cells (HUVEC) cultured under static conditions and in modeled microgravity for 24 h was studied by chromatography-mass spectrometry. In the secretome of cells exposed to microgravity, we identified a group of microtubule proteins including many structural elements of microtubules and regulatory proteins interacting with Rho-GTPases. Hence, reorganization of actin cytoskeleton and microtubules induced by microgravity is under complex regulation mediated by Rho proteins.

Original languageEnglish
Pages (from-to)35-38
Number of pages4
JournalBulletin of Experimental Biology and Medicine
Issue number1
Publication statusPublished - 15 May 2019
Externally publishedYes


  • chromatography-mass spectrometry
  • endothelial cells
  • microtubules
  • Rho-GTPases
  • secretome


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