Search for Alternative RNA Secondary Structures Regulating Expression of Bacterial Genes

E. V. Lyubetskaya, L. A. Leont'ev, M. S. Gelfand, V. A. Lyubetsky

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Expression of many bacterial genes is regulated by formation of alternative secondary RNA structure within the leader mRNA sequence. Our algorithm designed to search for these structures (basing on analysis of one nucleotide sequence) was applied to analyze operons of amino acid biosynthesis in alpha- and gamma-proteobacteria. The attenuators of these operons are predicted for genomes of some poorly known gamma-proteobacteria including Shewanella putrefaciens, attenuators of the tryptophan operon in some alphaproteobacteria are also predicted.

Original languageEnglish
Pages (from-to)707-715
Number of pages9
JournalMolecular Biology
Volume37
Issue number5
DOIs
Publication statusPublished - Sep 2003
Externally publishedYes

Keywords

  • Attenuator structure
  • Expression regulation
  • Proteobacteria
  • Search algorithm

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