Scalable simulation of realistic volume fraction red blood cell flows through vascular networks

Libin Lu, Matthew J. Morse, Abtin Rahimian, Georg Stadler, Denis Zorin

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

8 Citations (Scopus)

Abstract

High-resolution blood flow simulations have potential for developing better understanding biophysical phenomena at the microscale, such as vasodilation, vasoconstriction and overall vascular resistance. To this end, we present a scalable platform for the simulation of red blood cell (RBC) flows through complex capillaries by modeling the physical system as a viscous fluid with immersed deformable particles. We describe a parallel boundary integral equation solver for general elliptic partial differential equations, which we apply to Stokes flow through blood vessels. We also detail a parallel collision avoiding algorithm to ensure RBCs and the blood vessel remain contact-free. We have scaled our code on Stampede2 at the Texas Advanced Computing Center up to 34,816 cores. Our largest simulation enforces a contact-free state between four billion surface elements and solves for three billion degrees of freedom on one million RBCs and a blood vessel composed from two million patches.

Original languageEnglish
Title of host publicationProceedings of SC 2019
Subtitle of host publicationThe International Conference for High Performance Computing, Networking, Storage and Analysis
PublisherIEEE Computer Society
ISBN (Electronic)9781450362290
DOIs
Publication statusPublished - 17 Nov 2019
Externally publishedYes
Event2019 International Conference for High Performance Computing, Networking, Storage and Analysis, SC 2019 - Denver, United States
Duration: 17 Nov 201922 Nov 2019

Publication series

NameInternational Conference for High Performance Computing, Networking, Storage and Analysis, SC
ISSN (Print)2167-4329
ISSN (Electronic)2167-4337

Conference

Conference2019 International Conference for High Performance Computing, Networking, Storage and Analysis, SC 2019
Country/TerritoryUnited States
CityDenver
Period17/11/1922/11/19

Fingerprint

Dive into the research topics of 'Scalable simulation of realistic volume fraction red blood cell flows through vascular networks'. Together they form a unique fingerprint.

Cite this