rRNA Methylation and Antibiotic Resistance

I. A. Osterman, O. A. Dontsova, P. V. Sergiev

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)

Abstract

Abstract: Methylation of nucleotides in rRNA is one of the basic mechanisms of bacterial resistance to protein synthesis inhibitors. The genes for corresponding methyltransferases have been found in producer strains and clinical isolates of pathogenic bacteria. In some cases, rRNA methylation by housekeeping enzymes is, on the contrary, required for the action of antibiotics. The effects of rRNA modifications associated with antibiotic efficacy may be cooperative or mutually exclusive. Evolutionary relationships between the systems of rRNA modification by housekeeping enzymes and antibiotic resistance-related methyltransferases are of particular interest. In this review, we discuss the above topics in detail.

Original languageEnglish
Pages (from-to)1335-1349
Number of pages15
JournalBiochemistry (Moscow)
Volume85
Issue number11
DOIs
Publication statusPublished - Nov 2020

Keywords

  • aminoglycosides
  • antibiotics
  • macrolides
  • methylation
  • ribosome

Fingerprint

Dive into the research topics of 'rRNA Methylation and Antibiotic Resistance'. Together they form a unique fingerprint.

Cite this