Role of the RNA polymerase sigma subunit in transcription initiation

Sergei Borukhov, Konstantin Severinov

Research output: Contribution to journalReview articlepeer-review

50 Citations (Scopus)


In bacteria, σ subunits direct the catalytically competent RNA polymerase core enzyme to promoters. Recent advances in our understanding of bacterial RNA polymerase reveal that σ subunits are intimately involved in all aspects of transcription initiation including promoter location, promoter melting, initiation of RNA synthesis, abortive initiation and promoter escape.

Original languageEnglish
Pages (from-to)557-562
Number of pages6
JournalResearch in Microbiology
Issue number9
Publication statusPublished - Nov 2002
Externally publishedYes


  • Initiation
  • RNA polymerase
  • Sigma subunits
  • Transcription


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