Ribosome: Lessons of a molecular factory construction

O. V. Sergeeva, P. V. Sergiev, A. A. Bogdanov, O. A. Dontsova

    Research output: Contribution to journalReview articlepeer-review

    4 Citations (Scopus)

    Abstract

    The ribosome is a macromolecular complex responsible for protein biosynthesis. Two subunits of the bacterial ribosome contain three RNA molecules of more than 4000 nt in total and more than 50 proteins. Ribosome assembly is an intricate multistep process, which is vital for the cell. The review summarizes the current concepts of the mechanisms sustaining bacterial ribosome assembly in the cell and in vitro model systems. Some details of assembling this machine are still unknown.

    Original languageEnglish
    Pages (from-to)468-484
    Number of pages17
    JournalMolecular Biology
    Volume48
    Issue number4
    DOIs
    Publication statusPublished - Jul 2014

    Keywords

    • Escherichia coli
    • GTPase
    • ribonucleoprotein complex
    • ribosome
    • RNA helicase
    • RNA methyltransferase
    • translation

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